Profhilo is pure hyaluronic acid that rehydrates and remodels the skin; Sunekos Performa is hyaluronic acid plus six amino acids that the skin uses to rebuild collagen and elastin; polynucleotides are purified DNA fragments that switch on the skin’s own repair. Profhilo suits dull, dehydrated skin with early laxity and takes 2 sessions. Sunekos suits thin, crepey skin on the cheeks, neck and under-eyes and takes four. Polynucleotides suit damaged, reactive, post-acne or very thin under-eye skin and take three. They are not interchangeable, and Dr Nish Shah MD, the Official UK Trainer for Sunekos, tells you which your skin needs at consultation.

The right booster depends on what your skin has lost, which Dr Nish identifies by examining the skin itself at consultation. If it looks flat, grey and dry, it has lost water: Profhilo. If it has gone thin and crepey, it has lost collagen and elastin: Sunekos Performa. If it is reactive, red, post-acne or paper-thin under the eyes, it has lost the ability to repair: polynucleotides. Many skins do well with two in sequence, and where the real problem is sagging rather than skin quality, Dr Nish recommends tightening or lifting first.

At Medisha Clinic in Mayfair, Profhilo is £350 per session or £700 for the course of 2; Sunekos Performa is £350 per session or £1,100 for the course of 4; polynucleotides are £350 per session or £950 for the course of 3. Profhilo for the neck or hands is £350 per area per session. Dermapen 4 microneedling is priced per session and course on its own page. A review after every course is included. Consultation with Dr Nish is £50, redeemable in full against treatment. The clinic is at 58 South Molton Street, Mayfair, London W1K 5SL, 3 minutes from Bond Street station.

No — skin boosters improve the quality of the skin you have; they do not lift tissue that has dropped or tighten skin that has loosened. Profhilo gives a mild firming as it remodels, but a sagging jawline needs Sofwave™ to tighten or PDO threads to lift, and a booster afterwards to improve the skin over the result. Dr Nish performs all of these and will tell you at consultation if your real problem is sagging rather than skin quality.

Profhilo needs 2 sessions 4 weeks apart, with glow visible from about 4 weeks after the first. Sunekos Performa needs 4 session 1 to 2 weeks apart, with the skin visibly thicker from the second and building for months. Polynucleotides need 3 sessions 2–4 weeks apart, with repair showing over the course. Results last 6–9 months and are kept with a single top-up session. Dr Nish reviews you 4 weeks after each course.

Downtime after a skin booster is minimal: each session leaves small raised bumps at the injection points that flatten within hours to a day, and mild redness for a day or two. You can go back to work the same day; make-up can go on after 12 hours. Heavy exercise, saunas, alcohol and facials are avoided for 48 hours. Dr Nish gives written aftercare and his direct contact details on the day.

Yes — Profhilo is designed for the neck, hands and décolletage as well as the face, and the neck is where it is often most visible. Sunekos Performa is used on the neck and under the eyes. Where the neck or chest skin has loosened rather than thinned, Sofwave™ tightens it first and the booster follows. Dr Nish assesses each area separately at consultation.

No — fillers add volume and change shape; skin boosters add hydration, collagen and repair and change nothing about the shape of the face. Profhilo and Sunekos are both hyaluronic acid, but they are formulated to spread through the skin rather than hold a shape. Nothing about a skin booster shows; the skin simply looks healthier. Where volume has been lost, that is a separate conversation about structural filler, and Dr Nish performs both.

Yes — the combinations are planned as one programme. Dermapen 4 microneedling rebuilds texture and pores, with Profhilo or Sunekos between or after sessions to improve the skin’s quality. Sofwave™ tightens loosened skin first, with a booster 4–12 weeks later to improve the tightened skin. Polynucleotides are often used first in damaged or reactive skin to make it ready for anything else. Dr Nish sets the order at consultation.

Most patients start in their 30s, when hydration and collagen first fall and the skin starts to look dull, but there is no fixed age; the decision is based on what your skin has lost. In the late 20s and 30s a single Profhilo course once or twice a year is often enough. From the 40s, thin and crepey skin usually needs Sunekos Performa, and sagging needs tightening or lifting first. Dr Nish assesses the skin itself, not the number.

Side effects are mild and temporary for most patients: small bumps and redness at the injection points for a day or two, occasionally a small bruise. Allergy to hyaluronic acid is very rare; Sunekos contains amino acids and polynucleotides are derived from fish, so known allergies are discussed at consultation. The rare but serious risk with any injectable is injection into a blood vessel, which Dr Nish is trained to recognise and manage. All risks are explained at consultation.

Medisha Clinic offers Profhilo, Sunekos Performa and polynucleotides under one roof, chosen for your skin and injected by Dr Nish Shah MD, the Official UK Trainer for Sunekos who teaches the protocol to other doctors. He is the Senior International Clinical Trainer at Derma Medical, Brand Ambassador and Key Opinion Leader for dermal fillers, and with over 30,000 non-surgical treatments one of the most experienced aesthetic doctors in the UK and London. Because he also performs Sofwave™ and thread lifts, you are never sold a booster for a face that needs lifting. Rated 5.0 on Google from 128 reviews. 58 South Molton Street, Mayfair, London W1K 5SL, serving Mayfair and Marylebone.