Profhilo is an injectable bio-remodelling treatment made from NAHYCO hyaluronic acid — high and low molecular-weight HA thermally bonded together with no chemical cross-linkers. Each treatment delivers 64mg of this ultra-pure HA through five Bio Aesthetic Points on each side of the face (ten injections in total) because the HA is not cross-linked it does not stay where it is placed: over the following days it spreads through the dermis, hydrating intensely and prompting fibroblasts and fat-cell stem cells to produce new collagen types I, III, IV and XVII and new elastin. That response is what the manufacturer calls bio-remodelling, and it is what makes Profhilo different from a filler (which adds volume) or a standard skin booster (which only hydrates). Two sessions four weeks apart are needed. Results appear from four weeks and peak eight weeks after the second session, lasting six to nine months. At Medisha Clinic every session is performed by Dr Nish Shah MD using The Medisha Method.

At Medisha Clinic in Mayfair a single Profhilo session is £350 and the recommended two-session protocol is £700. Neck and hands are £350 per area per session. Maintenance after a completed protocol is £350. Consultation with Dr Nish is £50, redeemable in full against treatment, so if you go ahead it costs nothing. A review is included after the protocol. The clinic is at 58 South Molton Street, Mayfair, London W1K 5SL, three minutes from Bond Street station.

Two, four weeks apart, and the four-week gap matters. The first session starts the bio-remodelling response. The second, delivered when that response is at its peak, amplifies it substantially. Studies and clinical experience agree that one session produces a noticeable but short-lived improvement in hydration, while two produce the tightening and firming Profhilo is known for. A third session is occasionally useful for very lax or sun-damaged skin. After the protocol, one maintenance session every six months keeps the result. At Medisha, because the second session is calibrated to your response to the first, patients rarely need more than that.

Most patients notice better hydration and a healthier glow around four weeks after the first session — just as the second session is due. After the second session the tightening builds, reaching its peak roughly eight weeks later, about twelve weeks from the start. That is when firmness, elasticity and luminosity are at their best and when your review photographs are taken. Results typically last six to nine months, varying with age, sun exposure and lifestyle because Profhilo remodels rather than fills, the decline is gradual. Your skin does not suddenly return to baseline, and a single maintenance session every six months holds you close to peak.

No. Profhilo and dermal fillers are both hyaluronic acid, but that is where the similarity ends. Fillers are cross-linked so they hold their shape and stay where they are placed. That is how they add volume to a cheek or reshape a nose. Profhilo is deliberately not cross-linked so that it spreads through the dermis instead of sitting in one spot. It adds no volume and cannot reshape anything. What it does is improve the quality of the skin itself — firmness, elasticity, hydration, luminosity, and tighten mild to moderate sagging. If you have lost volume you need filler. If your skin has become lax and dull you need Profhilo. Many patients need both, and they can be combined in a planned programme. Dr Nish performs both and will tell you which addresses what you are seeing.

Both are injectable skin-quality treatments performed by Dr Nish, but they work differently and suit different skin. Profhilo is pure NAHYCO HA that spreads through the dermis, hydrating intensely and triggering bio-remodelling. It excels at sagging and dehydration on the face and neck and needs two sessions. Sunekos combines HA with six amino acids that fibroblasts use directly to build collagen and elastin. It excels at crepey texture, fine lines and thin under-eye skin, is safe under the eyes where Profhilo is not used, and needs four sessions. In practice: lax and tired-looking skin — Profhilo. Crepey, fine-lined or thin skin, or under-eye concerns — Sunekos. Both, in sequence, for comprehensive skin quality. Dr Nish is the Official UK Trainer for Sunekos and performs both, so his recommendation is based on your skin.

For skin tightening and regeneration, yes, and the mechanism explains why. Traditional skin boosters use lightly cross-linked HA injected as many small deposits across the face. The HA stays where it is placed and hydrates locally, giving a temporary plumped, dewy look that fades in four to six months. Profhilo uses non-cross-linked NAHYCO HA at ten points, which spreads through the tissue and triggers a genuine collagen and elastin response — bio-remodelling. That tightens the skin and lasts six to nine months. Skin boosters remain a reasonable choice for a short-term glow before an event. For lasting improvement in firmness and quality, Profhilo is the stronger treatment and the better-evidenced one.

Profhilo is one of the most comfortable injectables: only ten injections per session, each a brief sting lasting a second or two, and most patients need no anaesthetic at all — topical cream is available if you prefer. Afterwards you will have a small raised bump at each point, which is normal and settles within 4–24 hours. Mild redness clears within a day and occasional bruising within a week. Most patients go straight back to work. For 24–48 hours avoid make-up on the area (12 hours), massaging the points, strenuous exercise, saunas, sunbeds, alcohol and active skincare. There is no restriction on flying or normal activities.

Yes. The neck is arguably where Profhilo performs best of all. Neck skin is thin, becomes crepey and lax early, and has few good treatment options; Profhilo’s spreading action suits it perfectly and the result is visibly firmer, smoother neck skin. The backs of the hands respond similarly, regaining plumpness and hydration without the lumpiness that filler can produce there. The décolletage benefits from restored density and luminosity in sun-damaged skin. Each area is treated as two sessions four weeks apart at £350 per session, and areas are often combined in one visit — face and neck together being the most common.

Yes, and the best skin results at Medisha usually come from a planned combination. Profhilo followed by Sunekos pairs hydration and tightening with targeted amino-acid regeneration — Dr Nish’s most-requested skin-quality programme. Profhilo alongside dermal filler treats skin quality and volume loss at the same time. Profhilo after a PDO Thread Lift improves the skin over the repositioned tissue so the lift looks better and lasts longer. Profhilo with anti-wrinkle injections addresses skin texture and expression lines together. Different injectables are usually spaced two to four weeks apart so each can be assessed; Dr Nish will design the sequence at consultation.

Profhilo has an excellent safety record and, because it contains only ultra-pure HA with no cross-linkers, an unusually low rate of reactions. Expected, temporary effects are the small bumps at each point for 4–24 hours, mild redness for a day and occasional bruising for up to a week. Uncommon effects include bumps persisting for a few days (usually from placement that is too superficial — avoided by correct depth), transient swelling, and, rarely, infection at an injection point. Allergic reaction is very rare because Profhilo is placed just under the skin at defined points away from major vessels, and is not a volumising product, the vascular complications associated with dermal fillers are far less relevant. But the injector still needs to know where the facial artery runs, which is why every Medisha session is performed by a medically trained doctor.

Because the person injecting is the person who trains other doctors. Dr Nish Shah MD is a medically trained doctor, Senior International Clinical Trainer at Derma Medical, Official UK Trainer for Sunekos, and Brand Ambassador and Key Opinion Leader for dermal fillers with a global manufacturer. He performs every Profhilo session himself using The Medisha Method — mapping your sagging, individualising the BAP points to your face rather than injecting the standard diagram, and calibrating the second session to how you responded to the first. He also performs Sunekos, polynucleotides and dermal filler, so his recommendation is based on your skin rather than on what he sells. Two-session protocol £700; £50 consultation redeemable. 58 South Molton Street, Mayfair, London W1K 5SL, three minutes from Bond Street. Also Marylebone.